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The RNA genome consists of at least seven structural landmarks (LTR, TAR, RRE, PE, SLIP, CRS, and INS), and nine genes (gag, pol, and env, tat, rev, nef, vif, vpr, vpu, and sometimes a tenth tev, which is a fusion of tat, env and rev), encoding 19 proteins.
Three of these genes, gag, pol, and env, contain information needed to make the structural proteins for new virus particles.
The resulting viral DNA is then imported into the cell nucleus and integrated into the cellular DNA by a virally encoded enzyme, integrase, and host co-factors.
Within these bodily fluids, HIV is present as both free virus particles and virus within infected immune cells.
Over half of the mass of the trimeric envelope spike is N-linked glycans.
The density is high as the glycans shield the underlying viral protein from neutralisation by antibodies.
This is one of the most densely glycosylated molecules known and the density is sufficiently high to prevent the normal maturation process of glycans during biogenesis in the endoplasmic and Golgi apparatus.
The unusual processing and high density means that almost all broadly neutralising antibodies that have so far been identified (from a subset of patients that have been infected for many months to years) bind to, or are adapted to cope with, these envelope glycans.best places to meet people online black woman looking to date white man free classified websites marriage counselling websites to meet women. where to meet successful men dating someone with depression?